It's a match that will likely decide who will automatically qualify for the Super W final next month.
The contest between the Queensland Women and NSW Waratahs is age-old rivalry and is also set to be a rematch of the 2018 Final.
With the Super W being just a five-week competition, the winner of the match will not only determine who takes top-spot on the table but the rights to host the final.
It also leaves the team in second to fight in a playoff match against third to determine who would advance to the final.
Waratahs coach Matt Evrard understands the importance of this game.
"It is a cut throat competition, you lose a game and that will cost you a home final, that’s pretty much how it works,” he said.
"The teams know how the structure of the comp has changed and that means you will be playing an extra week or you get a bye week.
“We all know that it could either be a curse or a hindrance so you're either going to take a bye week and go into a grand final or you're going to play a second or third game potentially at a home venue where you can build momentum."
The Waratahs will be hoping to pick up where they finished last round after a 112-0 thrashing of the Rebels.
For Queensland, they are coming off a bye in round three but will be without Liz Patu after she received a six-match ban for biting Rebecca Clough.
Catch the age-old interstate rivalry on Sunday March 10 from 2pm at Leichhardt Oval.