Madison de Rozario had put the world on notice after completing a clean sweep of her events at the Nottwil Grand Prix.
She had already won the 800m on Friday before taking out the 1,500m in world record time.
The 24-year-old defended her 5,000m T54 crown from 2017 against a strong field including US duo Tatyana McFadden and Susannah Scaroni.
The Para athletes pulled clear from the rest of the field early before de Rozario took the lead in the final few laps.
“I definitely thought I was going to get caught coming around the last 200m as these girls are all incredibly strong, but I managed to hold off to the line so I’m really happy with that race,” de Rozario told the International Paralympic Federation.
It was her sixth appearance on the podium this year after winning double gold at the Commonwealth Games and first place at the London Marathon.
“It’s been so surreal," de Rozario said.
"There was a lot of focus going into the Commonwealth Games and that definitely took up all of my thoughts for the first part of the year.
“Then to refocus on the London Marathon – that itself was a massive surprise and I’ve definitely hit a good patch of form at the moment.
"I’m really hoping we can stretch it out a bit longer,” she said.