It will be the first time the two sisters have ever faced each other.

Both played at Sydney FC for several seasons together before Leena made the switch to Western Sydney Wanderers and Sham to Canberra United ahead of this W-League season. 

The family has been talking about the matchup for a few weeks now with the family torn on who to support. 

"It's been a funny couple of weeks, me and my sister feel sorry for our family because they are torn," Leena said.

"They are going to go neutral. They are going to support both of us.

"We don't know what is going to happen on the day, whether I score or she saves it but whatever happens the family will be proud either way," she said.

Taken by Stephanie Meek (@stephaniemeekphotgraphy)

Leena is set to become the 13th W-League player to join the 100 club and becomes just the second player this season behind Katrina Gorry to reach the milestone. 

It's an exciting moment for the 32-year-old who has been part of the competition since day one.

"I'm excited for a couple of things," Khamis said.

"Finally I've reached 100 games in the W-League after 11 seasons. I had two seasons where I had to overcome a few hurdles with an injury.

"Also I play against my sister for the first time ever so it makes it doubly special," she said.

Khamis had a debut to remember back on October 25, 2008, when Sydney FC faced Perth Glory in the inaugural W-League match. 

Khamis had her name put into the history books having scored the first ever W-League goal and also being the first player to score a double.

Khamis went on to win the Golden Boot that season scoring 10 goals in the 10 round season. From there she has gone on to win two Premierships (2009 & 2010/11) and a Championships (2009) which all came with Sydney FC.

"When I reflect back and I think 'wow, this is my 11th season that I've been playing'," Khamis said.

When Khamis steps out onto Spotless Stadium tonight, she says she will still have the same feeling she had from that first season.

"It's still the same feeling from my first game to my 100th game, I still play the same way, with the same passion and commitment," she said.

"It's an honor to reach 100 games in the W-League," Khamis said.

Catch Leena Khamis milestone match tonight on FoxSports 505 and SBS Viceland as the Wanderers take on Canberra from 5:20pm.