The world No.8 capitalised on eight break-point chances to see a 6-4 6-4 victory over the Australian. No.1.

Barty had Pliskova under pressure for most of the game, striking 29 winners to Pliskova’s 16, six aces to four, and offering up only two break points on serve, however, it didn't reflect on the scoreboard.

“It’s disappointing because I know that wasn’t my best tennis today that I’ve played across the past month but she did play the big points better today,” Barty told AAP.

While her run at the US Open comes to an end, it has been a breakout Grand Slam for the 22-year-old who will now reach a career-high of No.15 when rankings come out next week.

The focus turns to the women's doubles for Barty with partner Coco Vandeweghe, who are back on the court tomorrow AEST in their Round of 16 clash.

“We get to go out there tomorrow and have some fun and keep enjoying this amazing week that we’ve had, and the last month in particular as well,” Barty said.

Meanwhile, Sam Stosur cruised to the quarter-final of the women's doubles with partner Zhang Shuai after a straight sets victory.

Ajla Tomljanović is also continuing her women's doubles campaign after bowing out in the second round and will be back on the court tomorrow with Magda Linette.