The Australian Diamonds will be looking to snatch the Quad Series trophy back from New Zealand when their campaign against South Africa beings in London.
The Quad Series in August 2017 didn't end well for the Diamonds as the lost the trophy to rivals New Zealand after their Round 3 match saw the Silver Ferns win 57-47.
The last time Australia faced South Africa, they put the Diamonds under immense pressure and led during the second quarter.
"We expect them to continue to grow, as they did between our two encounters last year," said Diamonds coach Lisa Alexander.
"South Africa really challenged us the last time we played in Canberra.
"Although we won by six goals in the end, they led halfway through the game and pushed us right to the final whistle," she said.
Australia has a different goaling line up from their last Quad Series, Susan Pettitt, Stephanie Wood and Gretel Tippett are all available to take the court while Paige Hadley and debutante Kate Moloney will be midcourt.
The match will be live on Channel 9 and streamed on the Netball live app from 2:15am AEDT Sunday 21 January (3:30pm GMT).